The invention relates to novel 25 disubstituted 6 trifluoromethylpyrimidine 4 3h one derivates to a method for the production thereof to the use thereof either alone or in combination for the treatment and or prevention of diseases and to the use thereof for producing medicaments for the treatment and or prevention of diseases in particular for the treatment and or prevention of . Although it was proposed some time ago that hyperpolarizabilities might be estimated from the results of x ray charge density refinements early results were unconvincing in this work we show that the one particle density obtained from the usual multipole refinement model does not contain sufficient information to determine these response properties and instead pursue the constrained
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